Brock Purdy lit up MNF for the 49ers against the Colts, throwing five TDs and making history with a mark not seen in 35 years ...

TD MNF night lifts the 49ers past the Colts and sets a clear path to the NFL Playoffs No. 1 seed with two home wins.

The Jaguars have everything in front of them over the next two weeks to allow them to take full advantage of the opportunity ...

Brock Purdy and the San Francisco 49ers made it look easy against the Indianapolis Colts on "Monday Night Football." ...

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how ...

Head coach Kyle Shanahan addressed the media after the game and provided several postgame injury updates, most notably on tight end George Kittle. Kittle suffered an ankle injury and did not return, ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

Associated PressLos Bills de Buffalo, Jaguars de Jacksonville y Chargers de Los Ángeles clasificaron a los playoffs de la ...

The San Francisco 49ers (11-4) kept pace in the NFC playoff picture with a 48-27 win over the Indianapolis Colts (8-7), whose once-bright season has taken a dark turn.

It all started on the kickoff after the 49ers scored their first touchdown of the game. Ameer Abdullah caught the ball, ran 18 yards, and dropped the ball. The veteran running back's mistake set San ...

San Francisco 49ers linebacker Dee Winters made a huge play in the fourth quarter to finish off the Indianapolis Colts.

The San Francisco 49ers head to Indianapolis for their final road trip of the regular season, taking on the Indianapolis Colts at Lucas Oil Stadium on ESPN's Monday Night Football. This matchup marks ...