Brock Purdy lit up MNF for the 49ers against the Colts, throwing five TDs and making history with a mark not seen in 35 years ...

TD MNF night lifts the 49ers past the Colts and sets a clear path to the NFL Playoffs No. 1 seed with two home wins.

The Jaguars have everything in front of them over the next two weeks to allow them to take full advantage of the opportunity ...

Brock Purdy and the San Francisco 49ers made it look easy against the Indianapolis Colts on "Monday Night Football." ...

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how ...

San Francisco 49ers defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterback Brock Purdy spoke to reporters after Friday's practice as the team gets ready for its Week 16 ...

Head coach Kyle Shanahan addressed the media after the game and provided several postgame injury updates, most notably on tight end George Kittle. Kittle suffered an ankle injury and did not return, ...

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers’ final pass 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

San Francisco 49ers quarterback Brock Purdy did a favor for three AFC teams by throwing five touchdown passes in a 48-27 ...

Associated PressLos Bills de Buffalo, Jaguars de Jacksonville y Chargers de Los Ángeles clasificaron a los playoffs de la ...

The San Francisco 49ers (11-4) kept pace in the NFC playoff picture with a 48-27 win over the Indianapolis Colts (8-7), whose once-bright season has taken a dark turn.