TD MNF night lifts the 49ers past the Colts and sets a clear path to the NFL Playoffs No. 1 seed with two home wins.

The Jaguars have everything in front of them over the next two weeks to allow them to take full advantage of the opportunity ...

Brock Purdy and the San Francisco 49ers made it look easy against the Indianapolis Colts on "Monday Night Football." ...

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how ...

San Francisco 49ers defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterback Brock Purdy spoke to reporters after Friday's practice as the team gets ready for its Week 16 ...

Head coach Kyle Shanahan addressed the media after the game and provided several postgame injury updates, most notably on tight end George Kittle. Kittle suffered an ankle injury and did not return, ...

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception of Philip Rivers’ final pass 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory ...

Christian McCaffrey accomplished a milestone he hasn't pulled off since 2023 during the 49ers' matchup against the Colts on ...

Here's what's known about Indianapolis' plans for its 44-year-old quarterback, and why it may make sense to stop playing Rivers.

San Francisco 49ers quarterback Brock Purdy did a favor for three AFC teams by throwing five touchdown passes in a 48-27 ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

Indianapolis Colts quarterback Philip Rivers throws a deep 33-yard pass to wide receiver Alec Pierce. Indianapolis Colts ...