The Indianapolis Colts host the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Live score updates, ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

The San Francisco 49ers visit the Indianapolis Colts in Week 16 of the NFL season. Follow along for highlights and live score ...

After a 1-yard gain by Christian McCaffrey and an incompletion from Brock Purdy, San Francisco faces third-and-goal. What a ...

The more impactful injury is Bortolini, who's since been replaced by Danny Pinter at the heart of the offensive line. The ...

The San Francisco 49ers may win their Week 16 matchup with the Indianapolis Colts, but they lost one of their best players to ...

Indianapolis Colts kicker Blake Grupe drills a 39-yard field goal. San Francisco 49ers tight end George Kittle grabs a ...

The early difference in this game came when the 49ers forced a fumble by Colts kick returner Ameer Abdullah after tying the ...

Monday Night Football closes out Week 16 with a huge matchup between the San Francisco 49ers and the Indianapolis Colts.

The 49ers are coming off a win over the Titans following their bye week, their fourth consecutive win after a loss to the ...

The San Francisco 49ers have been one of the most injured teams thoughout the entire 2025 season. While the team will never ...

Waymos stopped in the middle of intersections during a mass power outage in San Francisco over the weekend, causing the ...