The Indianapolis Colts host the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Live score updates, ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

The San Francisco 49ers visit the Indianapolis Colts in Week 16 of the NFL season. Follow along for highlights and live score ...

Brock Purdy replied in kind after Philip Rivers opened the scoring with a TD pass against the 49ers. Purdy responded with 2!

After a 1-yard gain by Christian McCaffrey and an incompletion from Brock Purdy, San Francisco faces third-and-goal. What a ...

Pro Bowl defensive tackle DeForest Buckner was activated off injured reserve and will play Monday night when the Indianapolis ...

The San Francisco 49ers may win their Week 16 matchup with the Indianapolis Colts, but they lost one of their best players to ...

It didn’t look like former San Francisco 49ers star DeForest Buckner would face his old team when he herniated a disk in his ...

Indianapolis Colts running back Ameer Abdullah fumbles the ball on the kick return for a San Francisco 49ers fumble recovery.

The Indianapolis Colts have lost starting center Tanor Bortolini for the rest of the game against the San Francisco 49ers in ...

The early difference in this game came when the 49ers forced a fumble by Colts kick returner Ameer Abdullah after tying the ...

The San Francisco 49ers have been one of the most injured teams thoughout the entire 2025 season. While the team will never ...