San Francisco safety Ji'Ayir Brown punched the football out of Indianapolis returner Ameer Abdullah, and tight end Jake Tonges jumped on the loose ball for the takeaway. San Francisco begins their second drive of the game at the Colts' 26 in a 7-7 game.

There are three AFC teams that will have full support for the 49ers when they face the Colts on Monday night. Three AFC teams will be in full support of the San Francisco 49ers when they take on the Indianapolis Colts on Monday night.

The San Francisco 49ers visit the Indianapolis Colts in Week 16 of the NFL season. Follow along for highlights and live score updates.

The Detroit Lions loss to the Pittsburgh Steelers on Sunday secured San Francisco's place in the NFC playoff field with three games remaining in the regular season. The result, paired with the 49ers Week 15 win over the Tennessee Titans at Levi's® Stadium, locked in another postseason appearance for San Francisco.

The Indianapolis Colts are looking to snap a four-game losing streak and get back into the AFC playoff picture Monday night.

One San Francisco 49ers rookie could be in line for his NFL debut when the 49ers visit the Indianapolis Colts on Monday.

The Indianapolis Colts are in must-win territory when they defend home turf against the San Francisco 49ers tonight.

A pair of teams fighting for the postseason but trending in different directions face off on Monday, Dec. 22 to close Week 16 as the Indianapolis Colts host the San Francisco 49ers.