The Colts playoff hopes are on life support after this latest loss—as their late season losing skid only continues.

The Colts are in danger of missing the postseason after a strong start to the 2025 regular season. Here are their playoff scenarios after Week 16.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.

Another win stacked up by the San Francisco 49ers. Their offense lit up the Indianapolis Colts in primetime to get the win with a score of 48-27. It was amazing

The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago Bears in Week 17 and then take on the Seattle Seahawks in Week 18. The Seattle-San Francisco regular-season finale could be the No. 1 overall seed in the NFC and the NFC West title.

Brock Purdy throws a career-high five touchdown passes and Dee Winters returns an interception 74 yards for a TD in a 48-27 win in Indianapolis. The Colts’ loss clinches playoff spots for the

By winning Monday night’s final regular-season road game in a 48-27 shootout over the Colts, the 49ers remained in control of their playoff destiny, which could include the NFC’s No. 1 seed for home-field advantage en route to Super Bowl LX at Levi’s Stadium.

The tightrope finally snapped inside Lucas Oil Stadium on primetime Monday Night Football as the Indianapolis Colts suffered a fifth straight loss in a 48-27 blowout against the San Francisco 49ers. What began as a hopeful holiday stage to showcase what was at one point the league’s most explosive offensive unit entering the Week 11